It soon became obvious that our emphasis needed to shift to the prevention and early (home) treatment of this catastrophic disease to prevent patients progressing to the pulmonary phase and requiring hospitalization.FLCCC Alliance
0.4 mg/kg immediately then repeat 2nd dose in 48 hours. Ivermectin is best taken with a meal or just following a meal (greater absorption). Ivermectin for pre-exposure prophylaxis (in HCW) and for prophylaxis in high-risk individuals (> 60 years with co-morbidities, morbid obesity, long term care facilities, etc). 0.2 mg/kg per dose – start treatment with one dose, 2nd dose 48 hours later, then 1 dose every 7 days (i.e. weekly).[13-18] For those at high risk of contracting COVID-19 we now recommend twice weekly dosing. See dosing Table below. Ivermectin has a number of potentially serious drug-drug interactions; please check for potential drug interactions at Ivermectin-Drug-Interactions –
Drugs.com (also see below) . The most important drug-drug interactions occur with cyclosporin, tacrolimus, anti-retroviral drugs, and certain antifungal drugs. The safety of ivermectin in pregnancy has not been determined.
200 ug/kg (0.2mg/kg) or fixed dose of 12 mg (≤ 80kg) or 18 mg (≥ 80kg).
Depending on the manufacturer ivermectin is supplied as 3mg, 6 mg or 12 mg tablets.
Weight – Dosage
50-64.9 kg – 12mg
65-79.9 kg – 15mg
80-94.9 kg – 18mg
95-109.9 kg – 21mg
≥ 110 kg – 24mg
Vitamin D3 1,000–3,000 IU/day (25-75 mcg). Vitamin D insufficiency has been associated with an increased risk of acquiring COVID-19 and from dying from the disease.
Vitamin C 500 – 1000 mg BID (twice daily). Vitamin C has important anti-inflammatory, antioxidant, and immune enhancing properties, including increased synthesis of type I interferons.
Quercetin 250 mg daily.
Quercetin has direct virucidal properties against a range of viruses, including SARS-CoV-2, and is a potent antioxidant and anti-inflammatory agent. Quercetin is a potent inhibitor of inflammasome activation, which believed to play a major role in the pathophysiology of the COVID-19 immune dysfunction. In addition, quercetin acts as a zinc ionophore. It is likely that vitamin C and quercetin have synergistic prophylactic benefit. A mixed flavonoid supplement containing quercetin, green
tea catechins and anthrocyanins (from berries) may be preferable to a quercetin supplement alone; this may further minimize the risk of quercetin related side-effects. It should be noted that in vitro studies have demonstrated that quercetin and other flavonoids interfere with thyroid hormone synthesis at multiple steps in the synthetic pathway. The use of quercetin has rarely been associated with hypothyroidism. The effect on thyroid function may be dose dependent, hence for chronic prophylactic use we suggest that the lowest dose be taken. Quercetin should be used with caution in patients with hypothyroidism and TSH levels should be monitored. It should also be noted quercetin may have important drug-drug interactions; the most important drug-drug interaction is with cyclosporin and tacrolimus.
Melatonin (slow release): Begin with 0.3 mg and increase as tolerated to 6 mg at night. Melatonin has anti-inflammatory, antioxidant, immunomodulating and metabolic effects that are likely important in the mitigation of COVID-19 disease.
Zinc 30–40 mg/day (elemental zinc). Zinc is essential for innate and adaptive immunity.In addition, Zinc inhibits RNA dependent RNA polymerase in vitro against SARSCoV-2 virus. Due to competitive binding with the same gut transporter, prolonged high dose zinc (> 50mg day) should be avoided as this is associated with copper deficiency. Commercial zinc supplements contain 7 to 80 mg of elemental zinc, and are commonly formulated as zinc oxide or salts with acetate, gluconate, and sulfate. 220 mg zinc sulfate contains 50 mg elemental zinc.